New

Principal Software Development Eng

Quanterix
tuition assistance, 401(k)
United States, Massachusetts, Billerica
Nov 20, 2025
Principal Software Development Engineer Billerica, MA (Hybrid) Quanterix is a global leader in ultra-sensitive biomarker detection, enabling breakthroughs in disease research, diagnostics, and drug development. Its proprietary Simoa technology delivers industry-leading sensitivity, allowing researchers to detect and quantify biomarkers in blood and other fluids at concentrations far below traditional limits. With more than 3,400 peer-reviewed publications, Quanterix has been a trusted partner to the scientific community for nearly two decades. In 2025, Quanterix acquired Akoya Biosciences, The Spatial Biology Company, adding multiplexed tissue imaging with single-cell resolution to its portfolio. Together, the combined company offers a uniquely integrated platform that connects biology across blood and tissue-advancing precision medicine from discovery to diagnostics. ROLE SUMMARY: The Principal Software Development Engineer is a senior member providing significant contributions to the architecture, design, development and test suite of Spatial Biology software products. Spatial Biology software products include GUI, instrument control layers (including firmware), image viewers, and image analysis software. This position may be the primary development lead on some products and will serve as the primary point of contact for more junior members. The Principal Software Development Engineer is also the liaison between the Software Team and other technical groups within the product development process. As you become an expert in Spatial Biology products, there will be opportunities to contribute to ultra-sensitive protein detection products as well. WHAT YOU'LL DO: Demonstrate significant knowledge in overall design, development, and delivery of Akoya's software solutions, particularly those used to interface with/control our instrument portfolio. Owns the design and development of significant portions of products, or entire small products themselves Owns the interaction between the hardware and software; primary diagnostician for potential hardware/software issues Capable of leading junior team members in construction and maintenance of the codebase Provides technical support and solutions to junior team members Works with minimal supervision; uses a wide degree of creativity and latitude to solve problems Handles software releases BASIC QUALIFICATIONS: Bachelor's degree in a related area (Master's in related area preferred) 10+ years of experience in software development. PREFERRED QUALIFICATIONS: Previous experience as a principal or Sr Software Developer, with increasing responsibilities over time Participate in cross-functional programs with the ultimate goal of developing products EXPECTATIONS, COMPETENCIES, SKILLS & ABILITIES: Billerica, MA (Hybrid (onsite as needed for work with the hardware (days can vary)) Expert knowledge of programming in C#, C++ Extensive experience working with .NET Framework , WPF and Winform solutions Experience with front and backend architecture (including authoring mockups as part of UI design) Experience with Microsoft Development tools (Visual Studio, MSBuild, powershell) Experience with various source code management systems (Github, Mercurial, Subversion) Experience with Test Drive Development/Unit test technologies (NUnit, XUnit, MSTest) Experience with Automation Test frameworks (FlaUI, Ranorex, Cypress) Experience with one or more aspects of instrument control, such as image acquisition (frame grabbers), XYZ stage control, stepper motors/encoder control, and/or fluidics control(syringe pumps, etc.). Familiarity with Agile development methodology Excellent verbal and written communication skills as well as team-building and interpersonal skills WHY YOU'LL LIKE WORKING WITH US: Our Technology: From discovery to diagnostics, Quanterix's ultrasensitive biomarker detection is fueling breakthroughs only made possible through its unparalleled sensitivity and flexibility. Simoa technology has delivered the gold standard for earlier biomarker detection in blood, serum or plasma, with the ability to quantify proteins that are far lower than the Level of Quantification (LoQ). Our industry-leading precision instruments, digital immunoassay technology and CLIA-certified Accelerator laboratory have supported research that advances disease understanding and management in neurology, oncology, immunology, cardiology, and infectious disease. Akoya Biosciences, a Quanterix company, is The Spatial Biology Company-bringing tissue context to life through high-resolution, single-cell imaging. Akoya's spatial phenotyping platforms help researchers visualize and measure how cells organize and interact within tissue to influence disease progression and therapeutic response. From discovery through clinical research, Akoya offers a full continuum of solutions, including PhenoCycler, PhenoImager Fusion and HT, and PhenoCode Panels. As part of Quanterix, Akoya complements a leading portfolio of ultra-sensitive biomarker detection technologies, together enabling a more complete view of biology and disease across both tissue and blood. Our Commitment to Employees: At Quanterix, our values are based on: Team, Innovation, Customer and Owner. Team: Challenge assumptions, not the person. Respect diversity of thought and hold ourselves to lofty standards Innovation: Stay curious, experiment, create and change Customer: Prioritize and celebrate these pioneers by doing our best to deliver on commitments Owner: Act with high integrity and in the best interest of Quanterix. Take measured risks and learn from their success and failures. We reward and recognize our employees by offering competitive compensation and a 401k plan with employer match, as well as competitive health, dental, and vision benefits for employees and their dependents. We also offer an unlimited vacation policy to all exempt employees, and a generous PTO policy for non-exempt employees. All employees are eligible for equity, employee stock purchase plan, a performance bonus, and 1:1 financial counseling/planning. We also offer Tuition Assistance. We have a free, state-of-the-art onsite fitness center for all employees. To keep you fueled up, we provide onsite employees free snacks and drinks every day! DIVERSE & INCLUSIVE WORKPLACE: Quanterix is committed to a Diverse and Inclusive workplace. We strive to recruit candidates who will bring inclusive mindsets and contribute to our values. Quanterix is an Equal Opportunity Employer and does not discriminate based on race, national origin, gender, gender identity, sexual orientation, protected veteran status, disability, age, or other legally protected status. Quanterix will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.