Computational Genomics Research Scientist, Next Generation Cells

Job Description

We are seeking a computational biologist with expertise in driving forward biological discoveries to join Vertex. This position is part of a global Data and Computational Sciences team focused on developing the next generation of cell therapies for Type 1 Diabetes. You will collaborate closely with a research team dedicated to discovering and actualizing the next generation of cell and genetic therapies in diseases. You will design multi-omic studies, develop and apply analyses, and interpret the outcome, while having a critical impact on the development of transformative therapies, and the understanding of cell biology. You will play a key role in innovating, evaluating, and applying cutting-edge computational methods that will enable us to make rapid, data-driven decisions. Proactive communication, and seamless cross-functional collaboration will be required for success in this role.

Key Duties and Responsibilities:

• Proactive collaboration with project teams, acting as the bioinformatics expert, to identify key project needs that can be addressed using bioinformatics contributions
• Evaluate therapeutic hypotheses via integration and quantitative analyses of internal & external multi-omics data sources including proteomic and sequencing data
• Partner with teams to plan studies that leverage multi-omic data to answer biological questions and define biological hypotheses to enable the next generation of cell therapies
• Perform sophisticated computational analyses of biological data, including proteomic data, through deep critical thinking, published findings and best practices from the field, strong statistics, and data science visualizations
• Distill complex analyses and scientific results into key take-home messages and recommendations for next steps to a broad audience
• Author study reports and white papers to support regulatory filings
• Partner with method development team members, identifying opportunities to improve usability, accuracy, and robustness of internal methods

Knowledge and Skills:

• Expertise in the computational analysis, visualization and interpretation of single and bulk-cell proteomic data
• Knowledge of the literature and field of multi-omic computational analysis of biological data
• Demonstrated ability to work across cross-functional teams, ensuring timely progress
• Superior communication skills, demonstrating condence and versatility in presenting verbally to diverse audiences and writing technical documents
• Expertise with rapidly applying computational methods and bioinformatics tools to large-scale data
• Proficiency with R, python and high-performance computing systems; solid understanding of statistics
• A team-oriented growth mindset that welcomes feedback from others and supports other team members; a positive attitude that enthusiastically tackles and overcomes challenges

Education and Experience:

• PhDdegree in computational biology, bioinformatics, genomics, systems biology, bioengineering, or a related field, with 0-3 years of productive, relevant industry or post-doctoral experience
• Master's degree in computational biology, bioinformatics, human genetics, genomics, systems biology, bioengineering, or a related field, with 3+ years of productive, relevant industry experience

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Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

In this Remote-Eligible role, you can choose to be designated as:
1. Remote: work remotely five days per week and come into the office on occasion - you're always welcome on-site; or select
2. Hybrid: work remotely up to two days per week; or select
3. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com